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Healthcare Engineering Innovation Group

Publications & Patents

  • Scientific impact
Scientific impact
  • Khandoker, A., Ibrahim, E., Oshio, S., & Kimura, Y. (2018). Validation of beat by beat fetal heart signals acquired from four-channel fetal phonocardiogram with fetal electrocardiogram in healthy late pregnancy. Scientific reports, 8(1), 13635.Journal Ranking (Scimago): Q1
  • Elayan, H., Stefanini, C., Shubair, R. M., & Jornet, J. M. (2018). End-to-end noise model for intra-body terahertz nanoscale communication. IEEE transactions on nanobioscience.Journal Ranking (Scimago): Q2
  • Romano D, Donati E, Benelli G, Stefanini C (2019). A review on animal-robot interaction: from bio-hybrid organisms to mixed societies. Biological Cybernetics. DOI: 10.1007/s00422-018-0787-5. Journal Ranking (Scimago): Q1
  • Shanti A, Teo J, Stefanini C (2018). In Vitro Immune Organs-on-Chip for Drug Development: A Review. Pharmaceutics (MDPI). Accepted for publication on November 21, 2018. Journal Ranking(Scimago): Q1
  • Jelinek H.F., Cornforth D, Khandoker, A. H. (Editors) “ECG Time Series Variability Analysis:  Engineering and Medicine” CRC Press/Taylor & Francis Group,  2016. ISBN 9781482243475. https://www.amazon.com/ECG-Time-Variability-Analysis-Engineering/dp/1482243474
  • Khandoker A.H., Al-Angari H.M, Lee S., Almahmeed W., Khalaf, K., Al Safar H.,Jelinek H.F., “Association of Diabetes Related Complications with Heart Rate Variability Among a Diabetic Population in the UAE”. PLOS One,  January 27, 2017. Publisher: PLOS One. http://dx.doi.org/10.1371/journal.pone.0168584 
  • Jelinek HF, Osman WM, Khandoker AH, Khalaf K, Lee S, Almahmeed W, Alsafar HS. Clinical profiles, comorbidities and complications of type 2 diabetes mellitus in patients from United Arab Emirates. BMJ Open Diabetes Research and Care. 2017 Aug 1;5(1):e000427.
  • Bayasi, N., Tekeste, T., Saleh, H., Mohammad, B., Khandoker, A.H, & Ismail, M. (2016). Low-power ECG-based processor for predicting ventricular arrhythmia. IEEE Transactions on Very Large Scale Integration (VLSI) Systems, 24(5), 1962-1974. [Best paper award in 2016]
  • Marzbanrad F; Khandoker A.H.; Hambly B; Ng E; Tamayo M; Lu Y; Matthews S; Karmakar C; Palaniswami M; Jelinek H, “Methodological Comparisons of Heart Rate Variability Analysis in Patients with Type 2 Diabetes and Angiotensin Converting Enzyme Polymorphism”. IEEE Journal of Biomedical Health and Informatics (IF: 3.45). Vol 20, Issue 1, pp 55 – 63; January 2016. DOI 10.1109/JBHI.2015.2480778.
  • Al Adem KM, Bawazir SS, Hassen WA, Khandoker AH, Khalaf K, McGloughlin T and Stefanini C. Implantable Systems for Stress Urinary Incontinence. Annals of biomedical engineering. 2017 Dec 1;45(12):2717-32. DOI: 10.1007/s10439-017-1939-9
  • Mencattelli M, Donati E, Spinelli P, Cultrone M, Luzi C, Cantarella D and Stefanini C. Measuring 3D-orthodontic actions to guide clinical treatments involving coil springs and miniscrews. Biomedical microdevices. 2017 Mar 1;19(1):14. DOI: 10.1007/s10544-017-0153-8
  • Ascari, L., Stefanini, C., Bertocchi, U., & Dario, P. (2010). Robot-assisted endoscopic exploration of the spinal cord. Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, 224(7), 1515-1529.
  • Mota C, Danti S, D’Alessandro D, Trombi L, Ricci C, Puppi D, Dinucci D, Milazzo M, Stefanini C, Chiellini F, Moroni L. Multiscale fabrication of biomimetic scaffolds for tympanic membrane tissue engineering. Biofabrication. 2015 May 7;7(2):025005. DOI: 10.1088/1758-5090/7/ 2/025005
  • Stefanini C, Menciassi A, Dario P. Modeling and experiments on a legged microrobotlocomoting in a tubular, compliant and slippery environment. The International Journal of Robotics Research. 2006 May;25(5-6):551-60. DOI: 10.1177/0278364906065876
  • Khalaf K.,Gan, DM, and Hemami, H. Dynamics and control of separable coupled rigid body systems (2017). Robotics and Biomimetics. 4(1): 1-14.
  • Liu T, Khalaf K,Naserkhaki S, El-Rich M. Load-sharing in the lumbosacral spine in neutral standing & flexed postures – A combined finite element and inverse static study (2017). Journal of Biomechanics.pii: S0021-9290(17)30573-0.
  • Khalaf K., Al-Angari, H., Khandoker A., Lee SM, Almahmeed W., Al Safar H., and Jelinek H. (2017). Gait Alterations in UAE Bedouin Population with and without Diabetic Complications. Gait and Posture. 58. 72-77.
  • Al-Angari H., Khandoker A., Lee SM, Almahmeed W., Al Safar H., Jelinek H., and Khalaf K. (2017). Novel dynamic peak and distribution plantar pressure measures on diabetic patients during walking. Gait and Posture. 51. 261-267.
  • Ashouri S, Abedi M., Abdollahi M., Manshadi M., Parnianpour M., and Khalaf K (2017). . Computers in Biology and Medicine. 89: 144-154.
  • Baltatzis, K. M. Bintsi, G. K. Apostolidis, and L. J. Hadjileontiadis, “Bullying incidences identification within an immersive environment using HD EEG-based analysis: A Swarm Decomposition and Deep Learning approach,” Nature Scientific Reports, 7(1), 17292, 2017.
  • Tsolaki, V. Kosmidou, I. (Y.) Kompatsiaris, C. Papadaniil, L. J. Hadjileontiadis, and M. Tsolaki, “Age-induced differences in brain neural activation during emotional stimuli: An HD-EEG Study,” Neuroscience, vol. 340, pp. 268-278, 2017.
  • K. Apostolidis and L. J. Hadjileontiadis, “Swarm decomposition: A novel signal analysis using swarm intelligence,” Signal Processing, vol. 132, pp. 40-50, 2017.
  • E. Iakovakis, F. A. Papadopoulou, and L. J. Hadjileontiadis, “Fuzzy logic-based risk of fall estimation using smartwatch data as a means to form an assistive feedback mechanism in everyday living activities,” Healthcare Technology Letters, 2016 (in press, DOI: 10.1049/htl.2016.0064).
  • D. Papadaniil and L. J. Hadjileontiadis, “Efficient Heart Sound Segmentation and Extraction Using Ensemble Empirical Mode Decomposition and Kurtosis Features,” IEEE Transactions on Biomedical and Health Informatics, vol. 18, no. 4, pp. 1138-1152, 2014.
  • Reda, A. Shalaby, M. Elmogy, A.AbouElfotouh, F. Khalifa, M. Abou El-Ghar, E. Hosseini-Asl, G. Gimel farb, N. Werghi, A. El-Baz, “ A Comprehensive Non-invasive Framework for Diagnosing Prostate Cancer”. Computers in Biology and Medicine, 2017, pp.148-158.
  • Taher F, Werghi N, Al-Ahmad H. Computer aided diagnosis system for early lung cancer detection. Algorithms. 2015 Nov 20;8(4):1088-110.
  • Vivekanand, N. Werghi, H. Al-Ahmad, “Multi-scale Roughness Approach for Assessing Posterior Capsule Opacification”,  IEEE Journal of Biomedical and Health Informatics, Vol.18, No.6,  pp. 1923 – 1931,  2014
  • F Taher, N Werghi, H. Al-Ahmad, C Donner, “Extraction and Segmentation of Sputum Cells for Lung Cancer Early Diagnosis”, Algorithms 6 (3), 512-531, 2013.
  • Berretti, N. Werghi,  A.D. Bimbo P. Pala,   Matching 3D Face Scans using Interest Points and Local Histogram Descriptors”, Computers & Graphics, Elsevier, Volume 37, Issue 5, 2013, pp. 509-525 DOI: 10.1016/j.cag.2013.04.001
  • Lee, S. M.; Eskin, S. G.; Shah, A. K.; Schildmeyer, L. A.; McIntire. L. V. Effect of zinc and nitric oxide on monocyte adhesion to endothelial cells under shear stress.  Biomed. Eng. 2012, 40, 697-706,  doi:10.1007/s10439-011-0434-y
  • Conway, D, Lee, S. M., Eskin, S, Shah, A., Jo, H., and McIntire, L., “Endothelial Metallothionein Expression and Intracellular Free Zinc Levels are Regulated by Shear Stress”, American Journal of Physiology – Cell Physiology, 2010, 299(6), C1461-C1467
  • Lee, S. M.; Al-Kaabi, L.; Mawart, A.; Khandoker, A.; Alsafar, H.; Jelinek, H. F.; Khalaf, K.; Park, J.-H.; Kim, Y.-C. Ultrasound-mediated drug delivery by gas bubbles generated from a chemical reaction.  Drug Target. 2017, 1-10. DOI: 10.1080/1061186X.2017.1354001
  • Rizk, N.; Christoforou, N.; Lee, S. M. Optimization of anti-cancer drugs and a targeting molecule on multifunctional gold nanoparticles.  Nanotechnology 2016, 27, 185704.DOI:  1088/0957-4484/27/18/185704/meta
  • Lee, S. M. Monocytes: a novel drug delivery system targeting atherosclerosis.  Drug Target.  2014, 22, 138-145 DOI:  10.3109/1061186X.2013.844158
  • Renda, M. Cianchetti, H. Abidi, J. Dias, L. Seneviratne “Screw-Based Modeling of Soft Manipulators with Tendon and Fluidic Actuation” ASME. J. Mechanisms Robotics, 2017;9(4):041012-041012-8.
  • Cacucciolo, F. Renda, E. Poccia, C. Laschi, M. Cianchetti “Modelling the Nonlinear Response of Fibre-reinforced Bending Fluidic Actuators” Smart Materials and Structures, 25:10, 2016.
  • Renda, F Giorgio-Serchi, F. Boyer and C. Laschi “Modeling Cephalopod-inspired Pulsed-jet Locomotion for Underwater Soft Robots” Bioinspiration & Biomimetics, 10:5, 055005, 2015.
  • Renda, M. Giorelli, M. Calisti, M. Cianchetti and C. Laschi “Dynamic Model of a Multibending Soft Robot Arm Driven by Cables,” Robotics, IEEE Transactions on, vol.30, no.5, pp.1109, 1122, Oct. 2014.
  • Renda, M. Cianchetti, M. Giorelli, A. Arienti and C. Laschi “A 3D Steady State Model of a Tendon-Driven Continuum Soft Manipulator Inspired by Octopus Arm” Bioinspiration & Biomimetics, 7 (2012), 025006.
  • Awad, M. I.; Gan, D.M.; Az-zu’bi, A.; Hussain, I.; Taha, T.; Stefanini, C.; Khalaf, K.; Zweiri, Y.; Dias, J.; Seneviratne, L. Passive Discrete Variable Stiffness Joint (pDVSJ-II): Modeling, Design, Characterization and Testing Towards Passive Haptic Interface. IEEE Access, under review, 2018.
  • Awad, M. I.; Gan, D.M.; Az-zu’bi, A.; Khalaf, K.;  Hussain, I.;  Dias, J.; Seneviratne, L. Novel Passive Binary-Controlled Variable Stiffness Joint (BpVSJ): Modeling, Characterization, and Testing Towards Passive Haptic Interface Application. IEEE Access, under review, 2018.
  • Khalaf, K.; Gan, D. M.; Hemami, H.; Dynamics and Control of Separable Coupled Rigid Body Systems. Robotics and Biomimetics. 2017, 4(14), 1-11. (doi: 10.1186/s40638-017-0068-0)
  • Gan, D.M.; Dai, J. S.; Dias, J.; Seneviratne, L. D. Variable Motion/Force Transmissibility of a Metamorphic Parallel Mechanism with Reconfigurable 3T and 3R Motion. Transactions of the ASME: Journal of Mechanisms and Robotics. 2016, 8(5), 051001_1-9. (doi: 10.1115/1.4032409)
  • Gan, D. M.; Dai, J. S.; Dias, J.; Umer, R.; Seneviratne, L. D. Singularity-Free Workspace Aimed Optimal Design of a 2T2R Parallel Mechanism for Automated Fiber Placement. Transactions of the ASME: Journal of Mechanisms and Robotics. 2015, 7(4), 041022_1-9. (doi: 10.1115/1.4029957)
  • Gan, D. M.; Tsagarakis, N. G.; Dai, J. S.; Caldwell, D. G.; Seneviratne, L. D. Stiffness Design for a Spatial 3-DOF Compliant Manipulator Based on Impact Configuration Decomposition. Transactions of the ASME: Journal of Mechanisms and Robotics. 2013, 5(1), pp. 011002(1-10). (doi: 10.1115/1.4007492)
  • Liu T, Khalaf K, Naserkhaki S, El-Rich M. “ Load-sharing in the lumbosacral spine in neutral standing & flexed postures – A combined finite element and inverse static study” J Biomech. 2017 Nov 6. pii: S0021-9290(17)30573-0. 
  • Arshad R, Angelini L, Zander T, Di Puccio F, El-Rich M, Schmidt H. “ Spinal loads and trunk muscles forces during level walking – A combined in vivo and in silico study on six subjects. ”  J Biomech. 2017 Aug 26. pii: S0021-9290(17)30432-3.
  • Naserkhaki S, Jaremko JL, El-Rich M. “Effects of inter-individual lumbar spine geometry variation on load-sharing: Geometrically personalized Finite Element study” J Biomech. 2016 Sep 6;49(13):2909-2917.
  • Naserkhaki S, Jaremko JL, Adeeb S, El-Rich M “On the load-sharing along the ligamentous lumbosacral spine in flexed and extended postures: Finite element study” J Biomech. 2016 Apr 11;49(6):974-982. doi: 10.1016/j.jbiomech.2015.09.050.
  • El-Rich M, Shirazi-Adl A, Arjmand N “Muscle activity, internal loads, and stability of the human spine in standing postures: combined model and in vivo studies” Spine. 2004 Dec 1;29(23):2633-42.
  • Srivastava V, Feng S, Cohen JD, Leonard NE, Shenhav A. (2017) A martingale analysis of first passage times of time-dependent Wiener diffusion models. Journal of Mathematical Psychology. doi:10.1016/j.jmp.2016.10.001
  • Feng S, Holmes P. (2016) Will big data yield new mathematics? An evolving synergy with neuroscience. IMA Journal of Applied Mathematics. doi:10.1093/imamat/hxw026
  • Schwemmer M, Feng S, Holmes P, Cohen J. (2015) A multi-area stochastic accumulator model for a covert visual search task. PLoS One 10(8):e 0136097. doi:10.1371/journal.pone.0136097
  • Feng S, Schwemmer M, Gershman S, Cohen J. (2014) Multitasking vs. multiplexing: Toward a normative account of limitations in the simultaneous execution of control-demanding behaviors. Cognitive, Affective, & Behavioral Neuroscience. doi:10.3758/s13415-013-0236-9
  • Feng S, Holmes P, Rorie A, Newsome WT. (2009) Can monkeys choose optimally when faced with noisy stimuli and unequal rewards? PLoS Computational Biology 5(2): e1000284. doi:10.1371/journal.pcbi.1000284
  • Bobby Mathew, AnasAlazzam, Saud Khashan, Ion Stiharu, Sawsan Dagher, Edward Furlani, “Fabrication of microfluidic devices with 3D embedded flow-invasive microelements” Journal of Microelectronic Engineering, 187-188, 27-32, 2018
  • Saud Khashan, AnasAlazzam, Mohammad Hamdan, Bobby Mathew, “Mixture Model for Biomagnetic Separation in Microfluidic Systems” Journal of Magnetism and Magnetic Materials, 422, 118-127, 2017
  • VahĂŠNerguizian, AnasAlazzam, Ion Stiharu and Miguel Jr. Burnier, “ Characterization of Several Cancer Cell lines at Microwave Frequencies” Journal Measurement, 109, 354-358, 2017
  • AnasAlazzam, Bobby Mathew, and Falah Alhammadi, “Novel microfluidic device for the continuous separation of cancer cells using dielectrophoresis” Journal of separation science, 40, (5),1193-1200, 2017
  • Bobby Mathew, AnasAlazzam, Saud Khashan, and Mohammad Abutayeh, “Lab-on-Chip for Liquid Biopsy (LoC-LB) based on Dielectrophoresis” Talanta, 164, 608-611, 2017
  • Zhang, Y.; Liao, K.; Li, C.; Lai, A. C.; Foo, J. J.; Chan, V. Progress in integrative biomaterial systems to approach three-dimensional cell mechanotransduction. Bioengineering 2017, 4, 72-92.
  • Das, D.; Phan, D. T.; Zhao, Y.; Kang, Y.; Chan, V.; Yang, C. A multi‐module microfluidic platform for continuous pre‐concentration of water‐soluble ions and separation of oil droplets from oil‐in‐water (O/W) emulsions using a DC‐biased AC electrokinetic technique. Electrophoresis 2017, 38, 645-652.
  • Zhang, Y.; Menon, N. V.; Li, C.; Chan, V.; Kang, Y. The role of bifurcation angles on collective smooth muscle cell biomechanics and the implication in atherosclerosis development. Biomaterials Sci. 2016, 4, 430-438.
  • Zhang, Y.; Li, C.; Chan, V.; Kang, Y. Biomechanistic study of smooth muscle cell sheet during circumferential alignment in circular microchannels. ACS Biomater. Sci. Eng. 2015, 1, 549-558.
  • Li, X.; Feng, H. X.; Chen, B.; Ng, S. S.; Chen, W. N.; Chan, V. Epigallocatechin-3-gallate (EGCG) Induced Modulation of Cell Deadhesion and Migration on Thermosensitive Poly(N-isopropylacrylamide), Journal of Biomedical Material Research A  2011, 98, pp. 450-460.
  • O. Rodrigues, L.O. Rodrigues, L.S.N. Oliveira, A. Conci and P. Liatsis, ‘Automated recognition of the pericardium contour on processed CT images using genetic algorithms’, Computers in Biology and Medicine, Vol. 87, pp. 38-45, August 2017.
  • O. Rodrigues, V.H.A. Pinheiro, P. Liatsis and A. Conci, ‘Machine learning in the prediction of cardiac epicardial and mediastinal fat volumes’, Computers in Biology and Medicine, Vol. 89, pp. 520-529, , 2017.
  • M. Jawaid, R. Rajani, P. Liatsis, C.C. Reyes-Aldasoro and G.G. Slabaugh, ‘A hybrid energy model for region based curve evolution- application to CTA coronary segmentation’, Computer Methods and Programs in Biomedicine, Vol. 144, pp. 189-202, June 2017.
  • Rajani, Y. Wang, A. Uus, D. Perera, S. Redwood, M. Thomas, J.B. Chambers, R. Preston, G.S. Carr-White and P. Liatsis, ‘Virtual Fractional Flow Reserve by coronary Computed Tomography: hope or hype’, Eurointervention, Vol. 9, No. 2, pp. 277-284, 2013.
  • Wang and P. Liatsis, ‘3-D quantitative vascular shape analysis for arterial bifurcations via dynamic tube fitting’, IEEE Trans Biomed Eng, Vol. 59, No. 7, pp. 1850-1860, 2012.
  • Abdel Wahab, J. Bentahar, H. Otrok, A. Mourad, Towards Trustworthy Multi-Cloud Services Communities: A Trust-Based Hedonic Coalitional Game. In the IEEE Transactions on Services Computing, Vol. 11, Jan – Feb 2018, IEEE.
  • KhosrowshahiAsl, J. Bentahar, R. Estrada, H. Otrok, R. Mizouni, B. Khosravifar, Dynamic Formation of Service Communities in the Cloud under Distribution and Incomplete Information Settings. In the Concurrency and Computation: Practice and Experience, Sept. 2017, Wiley.
  • Estrada, R. Mizouni, H. Otrok, A. Ouali, J. Bentahar, A Crowd-Sensing Framework for Allocation of Time-Constrained and Location-based Tasks. In the IEEE Transactions on Services Computing, Vol., July 2017, IEEE.
  • AlMahmoud, E. Damiani, H. Otrok, Y. Al-Hammadi, Spamdoop: A privacy-preserving Big Data platform for collaborative spam detection. In the IEEE Transactions on Big Data, Vol., June 2017, IEEE.
  • Abdel Wahab, J. Bentahar, H. Otrok, A. Mourad, Optimal Load Distribution for the Detection of VM-based DDoS Attacks in the Cloud. In the IEEE Transactions on Services Computing, Vol., April 2017, IEEE.
  • Ying Zhang, Kin Liao, Chuan Li, Alvin C.K. Lai, Ji-Jinn Foo, and Vincent Chan, “Progress in Integrative Biomaterial Systems to Approach Three-Dimensional Cell Mechanotransduction,” Bioengineering, 4(3), 72 (2017); doi:10.3390/bioengineering4030072
  • Li, YQ; Huang, P; Zhu, WB; Fu, SY; Hu, N; Liao, K, “Flexible wire-shaped strain sensor from cotton thread for human health and motion detection,” SCIENTIFIC REPORTS, Vol.7, Article Number: 45013, MAR 21 2017 [DOI: 10.1038/srep45013]
  • Abdulsamad, Yuanqing Li, Andreas Schiffer, Saeed M. Alhassan, Kin Liao, “Graphene foam developed with a novel two-step technique for low and high strains and pressure sensing applications”, Small, (2015) [DOI: 10.1002/smll.201403532]
  • Goh, K. L. et al, “A thermomechanical framework for reconciling the effects of ultraviolet radiation exposure time and wavelength on connective tissue elasticity”, Biomechanics and Modeling in Mechanobiology, 13(5) pp.1025-1040 (Oct 2014) [DOI 10.1007/s10237-013-0551-7]