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ABDUL RASHEED PALAKKOTT
Mr. abdul palakkott Research Associate Biological Sciences

Contact Information
abdulrasheed.palakkott@ku.ac.ae

Biography

Abdul Rasheed Palakkott is a BSc Polymer Chemistry degree holder from the University of Kannur, India, and also holds an MSc degree in Biotechnology from Periyar University, India. He served as a Research Associate in the Department of Biology at United Arab Emirates University for more than 8 years and contributed successfully to several research projects such as the role of the Spike protein and its Receptor-Binding Domain to target the EGF receptor, the possible interactions between the  AT1R and PAR1 receptors, the functional action of Lactoferrins on insulin receptors, etc, under the supervisions of Prof Mohammed Akli Ayoub and Prof. Rabah Iratni. During his MSc, he investigated the Application of the Methanolic extract of Quassia amara in a PC-3 cancer cell line with Prof. Akbarshah at Bharatidasan University, India. Mr. Abdul Rasheed also holds pharmaceutical industry experience as he worked as a Quality control Chemist at CIPLA Bangalore, India.


Education
  • Master of Science in Biotechnology
  • Bachelor of Science in Polymer Chemistry



Research
Research Interests
  • Cancer and Diabetes
  • Cell surface receptor pharmacology and signaling

Research Projects

  • The role of the spike 1 S protein and its receptor-binding domain (RBD) to target the epidermal growth factor receptor (EGFR): The SARS-CoV-2 virus, at the molecular and cellular levels, exploits the spike S protein to invade lung cells through its interaction with the transmembrane receptor ACE2. Aimed to uncover other molecular targets and pathways that might be utilized by SARS-CoV-2. Using the lung cancer cell line A549 cells in vitro, examined the possibility of the spike 1 S protein and its RBD interacting with EGFR and its downstream signaling pathway.

  • Cell Surface Receptor Pharmacology and Signaling, the possible interactions between the  AT1R and PAR1 in the target tissues: The interplay between receptors for various signal molecules, such as hormones, neurotransmitters, and cytokines, plays a crucial role in regulating the transmission of signals and contributing to physiological diversity. Building on this concept, this study delved into the potential relationship between receptors for the pivotal RAS hormone, angiotensin II, and the protease thrombin in target tissues.

  • The functional action of Lactoferrin purified from camel and bovine milk on insulin receptors (IR): Lactoferrin is a milk protein that may be an interesting candidate for the anti-diabetic properties of milk due to its well-documented bioactivity and implication in diabetes. Investigated the functional action of LF purified from camel and bovine milk on insulin receptors (IR) and their pharmacology and signaling in endogenously IR-expressed HepG2 and transiently IR over expressed  HEK293 cells.