Osteoarthritis, a degenerative joint disease, is a leading cause of disability worldwide. Despite its prevalence, the molecular mechanisms driving disease progression remain poorly understood. It is, however, known that catabolic and inflammatory responses initiate early degenerative changes in the chondrocytes. Our research has identified periostin, a matricellular and matrix protein, as a trigger for a catabolic cascade in chondrocytes. However, there is limited information on the factors and mediators that can reverse or protect against the catabolic effects of periostin in these cells. This project aims to elucidate the mechanisms by which growth factors and anti-inflammatory agents mitigate periostin-induced catabolic responses in chondrocytes.
1. Understand osteoarthritis and its basic, translational, and clinical significance
2. Understand the mechanistic role of periostin in the progression of osteoarthritis
3. Acquire hands-on experience in laboratory techniques such as cell culture, RNA extraction, and PCR
4. Develop skills in experimental design, data analysis, interpretation, reporting, and presentation
Advanced understanding of molecular and cell biology • Complete and maintain EHS laboratory safety training • Excellent writing and communication skills • Ability to develop and maintain laboratory research protocols • Ability to work as a team
